Clinical Findings and Medical Management of Hospitalized Patients with Rheumatoid Arthritis in Western Algeria: a Retrospective Study


  • Siheme OUALI Department of Biology, Djillali Liabes University of Sidi bel Abbes, Laboratory of Molecular Microbiology, Proteomics and Health, Algeria
  • Khalida ZEMRI Department of Biology, Djillali Liabes University of Sidi bel Abbes, Algeria
  • Ferial SELLAM National Research Center of Biotechnology. CRBT
  • Noria HARIR Department of Biology, Djillali Liabes University of Sidi bel Abbes, Algeria Laboratory of Molecular Microbiology, Proteomics and Health, Algeria
  • Zahira BENAISSA Department of Biology, Djillali Liabes University of Sidi bel Abbes, Algeria
  • Sid Tadj HEBRI Department of internal medicine, CHU Sidi BelAbbes,Algeria
  • Ouassini BENSABER Department of functional rehabilitation, CHU Sidi Bel Abbes, Algeria
  • Zouaoui NADJI Department of internal medicine, CHU Sidi BelAbbes,Algeria


Clinical Characteristics, Rheumatoid Arthritis Patients, Treatment, Western Algeria Region


Introduction: Rheumatoid arthritis is the most common inflammatory rheumatic disease in adults and chronic autoimmune disease with a prevalence of 0.5% in the world. It is four times more frequent in women than in men. The aim of this study was to determine the clinical, para-clinical, and therapeutic parameters of patients with rheumatoid arthritis in Western Algerian region (Sidi bel Abbes area in particular).

Methods: We carried out a retrospective study based on medical records over 300 patients with RA diagnosed between 2015-2019 in the internal medicine department and functional rehabilitation department of the University Hospital of Sidi Bel Abbes. All data were processed and analyzed via SPSS 22.0 (Statistical Package for the Social Sciences, IBM Corporation; Chicago, IL. August 2013).

Results: out of all the enrolled participants in our study, 85.7 % were females and 14.3% were males, the mean age of diagnosis was 52,717±12,2273, ranging from 14 to 84 years old. The average time of disease duration was 4,173±3,9381 years. 53.7% of  the subjects had moderate activity, and 45% were menopausal. The main medical histories were high blood pressure (41%) type 2 diabetes  (84.7%), hypothyroiditis  (06%) and osteoporosis (4.7%).  81.3% of patients were seropositive and 46.51% of smokers had a highly seropositive ACPA(Anti Citrullinated Peptides Antibodies) (p=0.002).Most patients used DAMRDS (Disease Modifying Anti-Rheumatic Drug) as treatment.


Conclusion: Our study has shown that relatively older adults are commonly affected; majority presented in moderate stage of the disease and more than the half of our patients were seropositive.



1. Guillemin F, Saraux A, Guggenbuhl P, et al. Prevalence of rheumatoid arthritis in France: 2001. Ann Rheum Dis 2005;64(10):1427‑30.
2. Combe B. Polyarthrite rhumatoide (PR) : quoi de neuf. J Radiol 2004;85(9):1231.
3. Aletaha D, Neogi T, Silman AJ, et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 2010;62(9):2569‑81.
4. Saraux A. Epidemiology of rheumatoid arthritis. Rev Prat 2012;62(8):1081‑3.
5. Pillon F, Michiels Y. Épidémiologie et physiopathologie de la polyarthrite rhumatoïde. Actual Pharm 2013;52(531, Supplement):1‑2.
6. Polyarthrite Rhumatoïde, 100.000 cas recensés en Algérie - Algé]. 2014. Available from:
7. Kvien TK, Uhlig T, Ødegård S, Heiberg MS. Epidemiological aspects of rheumatoid arthritis: the sex ratio. Ann N Y Acad Sci 2006;1069:212‑22.
8. Chabchoub G, Uz E, Maalej A, Mustafa CA, et al. Analysis of skewed X-chromosome inactivation in females with rheumatoid arthritis and autoimmune thyroid diseases. Arthritis Res Ther 2009;11(4):R106.
9. Slimani S, Abbas A, Ben Ammar A, et al. Characteristics of rheumatoid arthritis in Algeria: a multicenter study. Rheumatol Int 2014;34(9):1235‑9.
10. Machado-Alba JE, Ruiz AF, Medina Morales DA. The epidemiology of rheumatoid arthritis in a cohort of Colombian patients. Rev Colomb Reumatol 2015;22(3):148‑52.
11. Andia A, Alassane S, Brah S, Daou M. La Polyarthrite Rhumatoïde à l’Hôpital National de Niamey. A propos de 42 cas. Rev Afr Médecine Interne. 27 déc 2016;3(2):29‑32.
12. Ferreyra M, Coiffier G, Albert J-D, David C, Perdriger A, Guggenbuhl P. La combinaison des données cytologiques et de la recherche des microcristaux dans le liquide synovial non purulent améliore les performances diagnostiques d’arthrite septique. Rev Rhum 2016;83(4):267‑73.
13. Gülfe A, Aletaha D, Saxne T, Geborek P. Disease activity level, remission and response in established rheumatoid arthritis: performance of various criteria sets in an observational cohort, treated with anti-TNF agents. BMC Musculoskelet Disord 2009;10:41.
14. Tantayakom P, Koolvisoot A, Arromdee E, Chiowchanwisawakit P, Muangchan C, Katchamart W. Le syndrome métabolique est lié à l’activité de la maladie chez les patients atteints de polyarthrite rhumatoïde. Rev Rhum 2017;84(5):412‑7.
15. Lehlou L, Akkar O, Lehraiki M, et al. Impact de la ménopause sur le profil lipidique au cours de la polyarthrite rhumatoïde. Rev Rhum 2016;83:A270.
16. Ajlani H, Yahia CBH, Abdelmoula L, et al. Influence du statut ménopausal sur le profil lipidique au cours de la polyarthrite rhumatoïde. Rev Rhum 2007;10‑11(74):1046.
17. Dougados M, Soubrier M, Antunez A, et al. Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA). Ann Rheum Dis 2014;73(1):62‑8.
18. Jeong H, Baek SY, Kim SW, et al. Comorbidities of rheumatoid arthritis: Results from the Korean National Health and Nutrition Examination Survey. Sung S-Y, éditeur. PLOS ONE 2017;12(4):e0176260.
19. Duncan H, Frost HM, Villanueva AR, Sigler JW. The osteoporosis of rheumatoid arthritis. Arthritis Rheum 1965;8(5):943‑54.
20. Alenfeld FE, Diessel E, Brezger M, Sieper J, Felsenberg D, Braun J. Detailed Analyses of Periarticular Osteoporosis in Rheumatoid Arthritis. Osteoporos Int 2000;11(5):400‑7.
21. Wolfe F. Comparative usefulness of C-reactive protein and erythrocyte sedimentation rate in patients with rheumatoid arthritis. J Rheumatol 1997;24(8):1477‑85.
22. Humphreys JH, Verstappen SMM, Hyrich KL, Chipping JR, Marshall T, Symmons DPM. The incidence of rheumatoid arthritis in the UK: comparisons using the 2010 ACR/EULAR classification criteria and the 1987 ACR classification criteria. Results from the Norfolk Arthritis Register. Ann Rheum Dis 2013;72(8):1315‑20.
23. Brunier L, Bleterry M, Merle S, et al. Prévalence de la polyarthrite rhumatoïde aux Antilles françaises : résultats de l’étude EPPPRA en Martinique. Rev Rhum 2018;85(4):346‑52.
24. Slimani S, Abbas A, Ben Ammar A, et al. Prevalence of metabolic syndrome in Algerian rheumatoid arthritis patients. Correlation with disease activity and functional status. Diabetes Metab Syndr 2017;11 Suppl 1:S425‑7.
25. Nishimura K, Sugiyama D, Kogata Y, et al. Meta-analysis: Diagnostic Accuracy of Anti–Cyclic Citrullinated Peptide Antibody and Rheumatoid Factor for Rheumatoid Arthritis. Ann Intern Med 2007;146(11):797.
26. Eriksson K, Nise L, Alfredsson L, et al. Seropositivity combined with smoking is associated with increased prevalence of periodontitis in patients with rheumatoid arthritis. Ann Rheum Dis 2018;77(8):1236‑8.
27. Källberg H, Ding B, Padyukov L, et al. Smoking is a major preventable risk factor for rheumatoid arthritis: estimations of risks after various exposures to cigarette smoke. Ann Rheum Dis. 2011;70(3):508‑11.
28. David JM, Mattei RA, Mauad JL, , et al. Clinical and laboratory features of patients with rheumatoid arthritis diagnosed at rheumatology services in the Brazilian municipality of Cascavel, PR, Brazil. Rev Bras Reumatol Engl Ed 2013;53(1):57‑65.
29. Toussirot É. Biothérapies des rhumatismes inflammatoires chroniques. Médecine Thérapeutique 2012;17(4):314‑21.






Original Article