Rhabdoid Tumor of the kidney in a five months old female infant: a case report


  • Daniel Hailu Addis Ababa University


Rhabdoid, Kidney, Hypercalcemia, Hypertension, Ethiopia


 Rhabdoid tumor of the kidney is a very rare disease with poor overall survival.   

 We report a five-month-old female infant with Stage IV Rhabdoid Tumor of the kidney,biopsy-proven, at a tertiary institution in Ethiopia. She presented with hematuria of 1-week duration and on physical examination had a  right palpable abdominal mass. She had stage II hypertension and persistent hypercalcemia which resolved after surgery.  A left radical nephrectomy and para-aortic lymph node excision were done and was started on chemotherapy. She died shortly after the first cycle.

 Reports from low-income countries are rare. Awareness may improve early detection and prognosis.


Beckwith JB, Palmer NF. Histopathology and prognosis of Wilms tumors: results from the First National Wilms’ Tumor Study. Cancer. 1978; 41(5):1937–1948. DOI: 10.1002/1097-0142(197805)41:5<1937::aid-cncr2820410538>3.0.co;2-u

Annual incidence of rhabdoid tumors among children <15, 2000-2008. Surveillance, Epidemiology, and End Results (SEER) Program; Bethesda, MD: 2011. Volume SEER17SEER*Stat version 7.0.6.

Vujanic GM, Sandstedt B, Harms D, et al. Rhabdoid tumour of the kidney: a clinicopathologicalstudy of 22 patients from the International Society of Paediatric Oncology (SIOP) nephroblastoma file. Histopathology. 1996; 28:333–340. https://doi.org/10.1046/j.1365-2559.1996.d01-436.x

Holger Moch, Peter A. Humphrey, and Thomas M. Ulbright, Victor E. Reuter (Eds): WHO Classification of Tumors of the Urinary System and Male Genital Organs (4th edition) IARC: Lyon 2016

Tomlinson GE, Breslow NE, Dome J, Guthrie KA, Norkool P, Patrick SL. R.M., et al. Rhabdoid Tumor of the Kidney in the National Wilms’Tumor Study: Age at Diagnosis as a Prognostic Factor. J Clin Oncol 23: 7641- 7645.

Ellen M. Chung, COL, MC, Grant E. Lattin, Jr, Lt Col, USAF, MC, Kimberly E. Fagen, CDR, MC, USN, Andrew M. Kim, CPT, MC, USA, Michael A. Pavio, CPT, MC, USA, Adam J. Fehringer, ENS, MSC, USN, et al. Renal Tumors of Childhood: Radiologic-Pathologic Correlation Part 2. The 2nd Decade: From the Radiologic Pathology Archives. Radiographics. September-October 2017; 37(5): 1538–1558.

C. J.Chung, R. Lorenzo, S. Rayder, E. Schemankewitz, C.D. Guy, J.Cutting, et al. Rhabdoid Tumors of the Kidney in Children: CT findings. AJR Am J Roentgenol 1995 Mar; 164(3):697-700

I Versteege , N Sévenet, J Lange, M F Rousseau-Merck, P Ambros, R Handgretinger,et al. Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer. Nature 1998 Jul 9;394(6689):203-6. doi: 10.1038/28212.

James I. Gellera, Jacquelyn J. Rothb, and Jaclyn A. Biegel . Biology and Treatment of Rhabdoid Tumor. Crit Rev Oncog. 2015; 20(3-4): 199–216

Amar, Aneesa M. M.D., Tomlinson, Gail M.D., Ph.D.; Green, Daniel M. M.D.; Breslow, Norman E. Ph.D.; de Alarcon, Pedro A. M.D. Clinical Presentation of Rhabdoid Tumors of the Kidney.

J Pediatr Hematol Oncol. 2001 Feb; 23 (2): 105-8. doi: 10.1097 / 00043426- 200102000-00007.

Marry M. van den Heuvel-Eibrink, Harm van Tinteren, Harriet Rehorst, Aurore Coulombe, Catharine Patte, et al. Malignant Rhabdoid Tumours of the Kidney (MRTKs), Registered on Recent SIOP Protocols From 1993 to 2005: A Report of the SIOP Renal Tumour Study Group. Pediatr Blood Cancer 2011; 56:733–737.