Severe Adverse Effects Associated with Multidrug Resistant Tuberculosis Medications among Patients attending ALERT Hospital, Ethiopia.


  • Yimer Seid Yimer Addia Ababa University



Background: Ethiopia is one of the countries with high MDR-TB burden. MDR-TB medications have sever adverse effects. However, little is known about adverse effects of MDR-TB medications in Ethiopia. Therefore this study is aimed at determining incidence of severe adverse effects associated with MDR-TB therapy.

Methods: A cross sectional study design using retrospective medical record review of 238 patients with Drug-Resistant Tuberculosis was conducted. Applying multiple logistic regression models, adjusted odds ratio and their 95% confidence intervals were used to select important risk factors associated with treatment adverse effects.

Results: One or more adverse effects developed in 219 cases (92 %). These effects led the clinicians to suspend one or more drugs from the treatment regimen in 46 cases (19.3%). Adverse effects observed most frequently include: Gastrointestinal Effect (79.4%), Hypokalemia (49.3%), Arthralgia (32%), Sleep Disturbance (13.7%), Psychosis (8.2%), Hypothyroidism (6.4%), Renal Toxicity (5.6%), Neuropathy (3.7%), and Hepatotoxicity (0.9%). Co morbid conditions of HIV/AIDS, and diabetes mellitus, older age group and homelessness were identified as important predictors of sever adverse effect.

Conclusion: Sever adverse reactions to MDR-TB therapy were common, and resulted in suspension of one or more drugs. We suggest that efforts should be made to continue treatment in the face of adverse effects. All diagnostic procedures and ancillary medications need to be always available for early detection, treatment and follow up of adverse events. Special attention should be given for elderly, homeless, HIV/MDR-TB, and Diabetes/MDR-TB co- infected patients.

Key words: Sever Adverse Effect, MDR-TB therapy, ALERT Hospital, Ethiopia

Author Biography

Yimer Seid Yimer, Addia Ababa University

Lecture at the departemnt of preventive Medicine , Addis Ababa University


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Original Article